Regional Missouri Bank, originally the Bank of Bynumville, was established in the Bynumville community in May 1908, with a capital stock of $10,000. Phillip Porter purchased the lot to build the bank for $50, and the bricks for the bank were made from the clay soil next to the bank. For a period of time, the second floor housed the local high school.

The bank's name changed to Regional Missouri Bank in 1978, and a second bank was built in Marceline in 1982. The Board of Directors decided to move the bank from Bynumville to Salisbury. Regional Missouri Bank opened in Salisbury in February 1997, to more conveniently serve our customers. Regional Missouri Bank Bank opened a third facility July 2000, located in downtown Marceline. In October 2006, Regional Missouri Bank acquired our fourth branch located in Keytesville, formerly known as the Bank of Keytesville. The fifth branch, located in Bucklin inside Prenger's Grocery Store, opened January 22, 2008.